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Phenotype screening platform of
C57BL/6J-MSM/Ms consomic strain panel.
Data set
QTL analysis
Data set

PhenoMap

Consomic Mouse Phenotype Panel

Data Comparison

Box Plot Scatter Plot statistics
Box Plot
Scatter Plot
Statistics

NIG Mouse Phenotype Database

NIG Mouse Phenotype Database

NIG Mouse Phenotype Database is used to identify latent genetic components underlying quantitative complex traits based upon mouse inter-subspecific genomic and phenotypic differences. An inbred strain MSM/Ms was established from Japanese wild mice, M. m. molossinus, collected in 1978 in Mishima, Shizuoka-ken, Japan (Moriwaki et al. 1994, 2009). It shows large extent of phenotypic difference in many complex traits, as well as vast amount of genome difference (0.82% SNPs), for a standard laboratory strain C57BL/6J (B6) (Abe et al. 2004). We have constructed a new full set of mouse consomic strains, using MSM/Ms as the chromosome donor and B6 as the host strain. We have systematically collected phenotype information of these inter-subspecific consomic strains, focusing on various complex traits (Takada et al. 2008), and it is still underway.

References
Moriwaki, K. 1994. Wild mouse from geneticist's viewpoint. In Genetics in wild mice: its applicatio n to biomedical research (eds. Moriwaki, K., Shiroishi, T., Yonekawa, H.), pp. xiii-xxiv, Japan Scientific Press and Karger, Tokyo
Abe, K. et al., 2004. Contribution of Asian mouse subspecies Mus musculus molossinus to genomic constitution of strain C57BL/6J, as defined by BAC end sequence-SNP analysis. Genome Research 14: 2439-2447.
Takada, T. et al., 2008. Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits. Genome Research 18: 500-508.
Moriwaki, K. et al., 2009. Unique Inbred Strain MSM/Ms Established from the Japanese Wild Mouse. Experimental Animals Vol. 58, No. 2 123-134

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This Database is supported by KAKENHI (Grant-in-Aid for Scientific Research) on Priority Areas "Comparative Genomics" from the Ministry of Education, Culture, Sports, Science and Technology of Japan.